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Sorghum bicolor como fonte de compostos alelopáticos para o manejo sustentável de Bidens pilosa
(Universidade Estadual de Goiás, 2026-08-27)
Silva, Natália Oliveira
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Souza, Flívia Fernandes de Jesus
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http://lattes.cnpq.br/7424287411637161
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Matos, Fábio Santos
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https://orcid.org/0000-0002-7666-006X
Blackjack (Bidens pilosa) is among the main invasive weeds in tropical agricultural systems, exhibiting high competitive ability and an increasing occurrence of herbicide-resistant biotypes. In this context, the use of allelopathic compounds of plant origin emerges as a sustainable alternative for weed management. The present study aimed to evaluate the allelopathic potential of sorghum (Sorghum bicolor) extract on the germination and early development of Bidens pilosa seedlings. The experiment was conducted in a completely randomized design, with six concentrations of sorghum extract (0, 10, 20, 40, 80, and 100%) and five replications. Germination (G), germination speed index (GSI), mean germination time (MGT), hypocotyl length (HL), radicle length (RL), fresh mass (FM), and dry mass (DM) of the seedlings were evaluated. The extract concentrations significantly affected germination, seedling vigor, and early growth. The sorghum extract promoted concentration-dependent responses. Lower concentrations stimulated some characteristics related to germination and early growth, whereas higher concentrations reduced germination, vigor, and biomass accumulation. Radicle length showed high sensitivity to the extract, with a progressive reduction as extract concentration increased. The 50% inhibitory concentration (IC₅₀) for radicle growth was estimated at 34.67% extract. The results demonstrate that sorghum extract has allelopathic and bioherbicidal potential against Bidens pilosa, and may constitute a complementary tool for sustainable weed management.
Composto pé de boi: alternativa na produção de mudas de aroeira
(Universidade Estadual de Goiás, 2026-08-04)
Vieira, Jéssica Karina Mesquita
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Lima, Roldão Carlos Andrade
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https://orcid.org/0000-0002-7239-2555
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http://lattes.cnpq.br/3335875582568538
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https://orcid.org/0000-0002-5054-1927
The production of seedlings of native forest species is a fundamental step in ecological restoration programs and is directly influenced by the physiological quality of the seeds and the growing conditions. In this context, the objective of this study was to evaluate seed germination and the initial development of seedlings of aroeira (Astronium urundeuva (M. Allemão) Engl.), a native species of high ecological and economic importance. In the first chapter, the effects of different temperatures and substrates on seed germination were evaluated using variables such as germination percentage, germination rate index, seedling length, and dry weight. The results showed that the species’ germination response varies depending on the conditions under which the germination test was conducted. In the second chapter, the potential of the organic compost “pé de boi” as a substrate component for seedling production was evaluated at different proportions mixed with soil and commercial substrate. The emergence rate index, height, collar diameter, number of leaves, dry mass, and Dickson quality index were analyzed. The results demonstrated that substrate composition significantly influences seedling development; moderate proportions of “pé de boi” compost yielded satisfactory performance, while high concentrations limited initial growth. Overall, the results obtained contribute to the improvement of aroeira propagation techniques, providing relevant information for germination tests, seedling production, and ecological restoration programs.
Revestimento comestível a base de fécula de mandioca e ácido salicílico na conservação pós colheita de tomate cereja
(Universidade Estadual de Goiás, 2026-06-26)
Assis, Valeska Cristina Souza Silva de
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Benett, Katiane Santiago Silva
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https://orcid.org/0000-0002-4324-959X
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http://lattes.cnpq.br/9175680309933313
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https://orcid.org/0009-0004-5678-020X
Postharvest technologies have gained prominence due to their ability to extend the shelf life of vegetables, meeting the increasing demand for products with good appearance and sensory quality. Among these technologies, the use of edible coatings based on natural polymers has shown promise due to low cost, biodegradability, and conservation efficacy. Cherry tomato (Solanum lycopersicum var. cerasiforme), although widely consumed, is highly perishable, re quiring effective preservation strategies. This study aimed to evaluate edible coating formula tions based on cassava starch combined with a phenolic compound for postharvest preservation of cherry tomatoes. The experiment was conducted in a completely randomized design with a 6 × 5 factorial arrangement, including six treatments (uncoated control; phenolic compound at 100 and 200 ppm; 3% cassava starch; 3% starch combined with phenolic compound at 100 and 200 ppm) and five storage periods (0, 10, 20, 30, and 40 days). Physical (mass loss and firm ness) and physicochemical (titratable acidity, pH, soluble solids, and SS/TA ratio) characteris tics were evaluated. However, fungal contamination was observed after the 30th day in starch coated treatments, highlighting the need for formulation or storage environment adjustments. The 3% cassava starch coating was the most effective in maintaining postharvest quality, pre serving global physical and physicochemical parameters. Salicylic acid showed limited effect, suggesting the need for application optimization. Nevertheless, formulation improvements will be essential to ensure microbiological stability during extended storage periods.
Estudo teórico da Interação do dabrafenibe com Nanotubos de Carbono
(Universidade Estadual de Goiás, 2026-02-20)
Rezende, Carlos Cézar Reis de Souza
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Santos, José Divino dos
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https://lattes.cnpq.br/2279900314020119
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https://lattes.cnpq.br/1224480599515577
This work investigated, through a quantum–classical approach, the interaction between the drug Dabrafenib (DAB) and carbon nanotubes (CNTs), aiming to evaluate the potential of these nanomaterials as controlled drug delivery systems for melanoma treatment. Initially, DFT calculations (B3LYP/6-31G(d)) were employed to optimize the structures and analyze the electronic properties of the CNT@DAB complex, revealing a strong affinity between the drug and the nanocarrier, with a formation energy of −245.99 kcal/mol, dominated by noncovalent van der Waals interactions. A reduction in the CNT band gap after DAB adsorption was also observed, indicating possible electronic modulation of the system. Subsequently, 100 ns molecular dynamics simulations performed in an aqueous environment using the OPLS-AA force field demonstrated high structural stability of the complex, with no drug desorption throughout the simulation. Overall, the results indicate that CNTs exhibit strong potential as efficient nanocarriers for Dabrafenib.
Hidróxidos Duplos Lamelares para a Co-entrega de amoxicilina e ibuprofeno: estudo da estabilidade e atividade Antimicrobiana
(Universidade Estadual de Goiás, 2020-06-30)
Silva, Kárita Karulina de Souza
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Rosseto, Renato
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https://orcid.org/0000-0003-4256-9062
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http://lattes.cnpq.br/2342305780810830
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http://lattes.cnpq.br/9373820717961090
Layered Double Hydroxides (LDH) are often described in the literature as a viable alternative for the encapsulation and carrying of drugs, since depending on the chemical composition, LDHs are biocompatible, chemically and thermally stable, in addition to exhibiting strong adsorption capabilities. and ion exchange. However, despite being potentially interesting, there are few studies that report the use of LDH in the simultaneous delivery (co-delivery) of different drugs. The co-delivery of active ingredients can represent advantages over conventional therapy, influencing bioavailability, stability, absorption and, eventually, synergy between the active ingredients. The present work aimed to study the stability, antimicrobial activity and modified release of amoxicillin (AMOX) and ibuprofen (IBU) present simultaneously in LDH. The LDHs of Zn/Al and Mg/Al and iron derivatives (HO-Fe) were prepared by coprecipitation at different temperatures (room and 75 0C) and pH (7.4, and 9), and the incorporations of AMOX and IBU to inorganic matrices were carried out by direct synthesis or by means of solid dispersions between drugs and inorganic matrix in the proportion 20% w/w (drug mass / inorganic solid mass). All compounds and dispersions were characterized by infrared spectroscopy (IR), scanning electron microscopy coupled to the dispersive energy spectrometer (SEM-EDS), thermogravimetric analysis (TG) and X-ray diffraction (XRD). The dosages of the drugs were performed by UV-vis spectroscopy and the antimicrobial activities of the solid dispersions were evaluated by colony counts through the inhibition of the Staphylococcus aureus bacteria. Preliminary studies have shown that the stability of AMOX is strongly influenced by the temperature and pH of the medium, regardless of whether it is in buffered solution or in solid dispersion. Differently, it was found for the IBU, which proved to be stable in the various conditions studied. The mode of incorporation of the active ingredients into the inorganic matrices, whether by direct synthesis or solid dispersion, did not influence the mode of release / solubilization of the drugs in buffer solution at pH 7.4, exhibiting greater than 50% desorption in up to 5 minutes of kinetics . However, the incorporations of AMOX and IBU by direct synthesis were not reproducible, in addition to exhibiting marked contamination by sodium chloride due to the preparation process. Thermogravimetric analyzes of the dispersions suggest that the inorganic matrices do not negatively affect the drugs, and that the IBU / AMOX co-presence is not harmful in terms of the thermal stability of the mixture. Under the conditions studied, LDH Zn/Al exhibited, when compared to other systems, a more pronounced action in inhibiting the growth of the microorganism, regardless of the presence of drugs. The results presented in this work open promising perspectives in the understanding and use of LDH and derivatives as host matrices of active principles in co-delivery systems.