Análise estrutural e topológica dos Favonóides Epicatequina e Chalcona Terpenóide

Abstract

The general class of flavonoids has been the target of several studies due to their pharmacological actions, such as anti-inflammatory, anti-carcinogenic, antiviral, antifungal, antibacterial, antimicrobial and antioxidant, being used also for treatments of cardiovascular diseases, allergies, among others. These properties can be related to the structural characteristics of each compound, such as functional groups, type of interactions, etc., thus demonstrating the importance of structural understanding for the analysis of the StructureActivity relationship. Based on this premise the flavonoids, epicatechin, and terpenoid-like chalcona (the first extracted from the Salacia crassifolia plant and the second obtained through the Claisen-Schmidt synthesis) were elucidated through X-ray diffraction, obtaining geometric parameters, topological analyzes, and theoretical calculations based on quantum mechanics. In this way, this dissertation becomes important due to all the structural elucidation presented, allowing future studies such as the analysis of Structure-Activity relationships of the compounds presented in this dissertation, and of future homologous structures obtained through syntheses.